Table 1.
Role of NK cells in graft rejection by γc+ or by γc− MI CD4+ T cells
| Donor T cells | ||
|---|---|---|
| Host | MIγc+Bcl-2+ | MIγγc− Bcl-2+ |
| NK+ | Rejection | Acceptance |
| NK− | Rejection | Acceptance |
Thymocytes from MI γc+ Bcl-2+ or MI γc− Bcl-2+ mice were adoptively transferred to NK cell-competent (Rag2−/−) or -deficient (Rag2−/−γc−/−) female hosts. One day later, male skin grafts were surgically placed. Graft acceptance or rejection was followed up to 120 days. Four recipient mice of each genotype were analyzed.