Fig. 5.

Presence of Seoul virus RNA is reduced after inactivation of regulatory T cells. Male rats were administered anti-CD25 mAb or vehicle alone and were inoculated with Seoul virus. At days 7 and 30 p.i., Seoul virus RNA was measured in the lungs by real-time RT-PCR. Because the amount of viral RNA in the lungs was not normally distributed, the median values are graphed, and scale bars indicate the 25th and 75th quartiles; statistically significant differences between vehicle-treated and anti-CD25-treated rats are indicated (*, P < 0.05).