Table 2.
Prediction of miRNAs with putative Tac1 mRNA 3′ UTR targets
miRNA | Sequence (5′ → 3′) | Tac1 target | Known targets |
---|---|---|---|
hsa_miR_130a | cag ugc aau guu aaa agg gca u | Yes | MAFB (24) |
hsa_miR_206 | ugg aau gua agg aag ugu gug g | Yes | hERα, connexin 43 (25, 26) |
hsa_miR_302a | uaa gug cuu cca ugu uuu ggu ga | Yes | ESC-specific, unknown (27) |
miRNA sequences of those increased in D12 MSCs and decreased by IL-1α (Table 1), and their known and predicted targets to Tac1 mRNA, as indicated by miRanda algorithm. Listed miRNAs are predicted to target one or more sites within the 3′ UTR of Tac1.