Table 2.
Pharmacokinetic parameters after an infusion of quinidine (4 mg kg−1) for 20 min and baseline values of heart rate and QTc in healthy subjects
| Korean | Caucasian | |||||
|---|---|---|---|---|---|---|
| Male (n = 12) | Female (n = 12) | Total (n = 24) | Male (n = 7) | Female (n = 6) | Total (n = 13) | |
| Cmax (mg l−1) | 2.63 ± 0.19 | 2.35 ± 0.23 | 2.49 ± 0.15 | 3.69 ± 0.60 (−1.45, −0.67) | 2.46 ± 0.33 (−0.39, 0.17) | 3.12 ± 0.39 (−0.81, −0.45) |
| AUC(0,12h) (mg l−1 h) | 10.28 ± 0.62 | 10.17 ± 1.03 | 10.22 ± 0.59 | 11.2 ± 1.03 (−1.71, −0.13) | 9.92 ± 0.99 (−0.83, 1.33) | 10.61 ± 0.71 (−0.83, 0.05) |
| AUC(0, ∞) (mg l−1 h) | 14.97 ± 0.83 | 13.67 ± 1.46 | 14.33 ± 0.83 | 14.73 ± 1.26 (−0.77, 1.25) | 13.21 ± 1.39 (−1.06, 1.98) | 14.03 ± 0.92 (−0.30, 0.90) |
| CLtot (l h−1 kg−1) | 0.28 ± 0.02 | 0.34 ± 0.04 | 0.31 ± 0.02 | 0.27 ± 0.02 (−0.05, 0.05) | 0.32 ± 0.04 (−0.11, 0.15) | 0.29 ± 0.02 (−0.06, 0.02) |
| Vss (l kg−1) | 2.85 ± 0.24 | 2.70 ± 0.23 | 2.78 ± 0.17 | 2.18 ± 0.21 (−0.09, 1.43) | 2.66 ± 0.26 (−0.77, 0.85) | 2.4 ± 0.17 (−0.14, 0.90) |
| Baseline heart rate (beats min−1) | 64 ± 5 | 66 ± 2 | 65 ± 1 | 62 ± 3 | 67 ± 2 | 64 ± 2 |
| Baseline QTc interval (ms) | 402 ± 9 | 443 ± 8* | 423 ± 7 | 421 ± 13 (−29.62, 8.38) | 445 ± 24 (−17.86, 13.86) | 438 ± 15 (−22.31, −7.68) |
Numbers in parentheses are 95% confidence intervals for difference in mean value between ethnic groups. Data are mean values ± SEM.
*
P < 0.05, anova test between male and female Korean subjects. Cmax; maximum plasma concentration, AUC(0,12h) and AUC(0,∞); area under the concentration-time curve from 0 to 12 h and infinity, CLtot; total clearance, Vss; volume of distribution at steady state.