Table 3.
Population pharmacodynamic parameters after a single 20 min i.v. infusion of quinidine (4 mg kg−1)
| E0 (ms) | ΔEmax (ms) | EC50 (µm) | ω2E0 | ω2Emax | ω2EC50 | σ2 | OBF | |
|---|---|---|---|---|---|---|---|---|
| Simple model | 425 (6.7) | 175 (19.1) | 3.73 (0.73) | 0.006 (0.002) | 0.08 (0.06) | 0.21 (0.19) | 0.004 (0.004) | 6687 |
| Adjusted model | 408 + [34*(1 − Sex)] (7.9) | (136*fETHN) +Cfemale (18.7) | 3.13 (0.71) | 0.004 (0.002) | 0.0002 (0.004) | 0.48 (0.20) | 0.004 (0.003) | 6650 |
Numbers in parentheses are the standard errors of the estimated parameters. OBF, minimum value of the objective function; ETHN, ethnicity: Korean = 1, Caucasian = 0; SEX, male = 1, female = 0; f ETHN:Korean = 1, Caucasian = 1.26; C female: Caucasian female = 106, all others = 0.