QTc-prolonging drugs having a clinically relevant proarrhythmic risk and defined daily dose (mg) [1]*
| Drug | 1 DDD | Drug | 1 DDD | Drug | 1 DDD |
|---|---|---|---|---|---|
| GI-prokinetics | Antipsychotics | Antimalarials | |||
| Cisapride | 30 | Chlorpromazine | 300 | Chloroquine | 500 |
| Domperidone | 30 | Droperidol | 15 | Halofantrine | 1500 |
| Cardiovascular | Haloperidol | 8 | Antihistamines | ||
| Indapamide | 2.5 | Pimozide | 4 | Astemizole | 10 |
| Ketanserin | 40 | Sultopride | 1200 | Diphenhydramine/ | 200 |
| Lidoflazine | 180 | Thioridazine | 300 | dimenhydrinate | |
| Probucol | 250 | Antidepressant | Promethazine | 25 | |
| Antibacterials | Amitriptyline | 75 | Terfenadine | 120 | |
| Clarithromycin | 500 | Clomipramine | 100 | Miscellaneous | |
| Erythromycin | 1000 | Doxepine | 100 | Pentamidine | 280 |
| Grepafloxacin | 400 | Mianserine | 60 | Tacrolimus | 5 |
| Cotrimoxazole | 1920 | Protriptyline | 30 | Terodiline | 50 |
| Sulfamethoxazole | 2000 | Zimeldine | 200 | ||
| Trimethoprim | 400 |
*
Clinical data do not provide a strong signal for fexofenadine, fluoxetine, clindamycin, levofloxacin, spiramycin and fluconazole [1]. These drugs are excluded from the original selection. DDD, Defined daily dose.