Table 1.
Characteristics of the study population
| Characteristics | Patients with ADRs (N = 385) % (n) | Patients without ADRs (N = 1633) % (n) | P-value |
|---|---|---|---|
| Age | 0.3 | ||
| 70–79 years | 17.4 (67) | 20.4 (333) | |
| 80–89 years | 54.8 (211) | 51.4 (840) | |
| ≥90 years | 27.8 (107) | 28.2 (460) | |
| Female | 72.2 (278) | 68.7 (1122) | 0.2 |
| Origin | 0.004 | ||
| Home-dwelling | 67.6 (227) | 75.3 (1096) | |
| Institution | 32.4 (109) | 24.7 (360) | |
| Use of inappropriate drugs | 70.6 (272) | 64.8 (1059) | 0.03 |
| Number of drugs (mean ± SD) | 7.3 ± 3.0 | 6.0 ± 3.0 | <0.0001 |
| Days of hospitalization (mean ± SD) | 13.7 ± 7.3 | 13.4 ± 8.7 | 0.5 |
| Comorbidity Index | 0.7 | ||
| 0 | 5.4 (21) | 6.6 (108) | |
| 1–2 | 28.6 (110) | 28.9 (472) | |
| 3–4 | 43.4 (167) | 44.3 (723) | |
| >6 | 22.6 (87) | 20.2 (330) | |
| Impaired renal function | 73.8 (284) | 68.8 (1124) | 0.06 |
| Dementia | 16.6 (64) | 19.7 (321) | 0.15 |
| Myocardial infarction | 19.5 (75) | 21.2 (347) | 0.5 |
| Congestive heart failure | 30.4 (117) | 25.4 (415) | 0.05 |
| Cerebrovascular disease | 16.6 (64) | 16.6 (271) | 0.99 |
| Chronic obstructive pulmonary disease | 20.6 (79) | 22.7 (371) | 0.35 |
| Connective tissue disease | 30.6 (118) | 30.9 (506) | 0.9 |
| Diabetes | 11.2 (43) | 10.7 (175) | 0.8 |
| Tumour | 15.3 (59) | 15.8 (258) | 0.8 |