Table 2.

Potentially inappropriate medications used on admission from the acute medical geriatric unit of Limoges University Hospital, and involved in ADRs and serious ADRs

	All patients (N = 2018) n (%)	Patients with ADRs (N = 385) n (%)	Patients with serious ADRs (N = 220) n (%)
Any inappropriate medication	1331 (66.0)	79 (20.5)	56 (25.5)
Antiemetic drugs with extrapyramidal properties	35 (1.7)	2 (0.5)	2 (0.9)
Cerebral vasodilators*	734 (36.4)	24 (6.2)	19 (8.6)
Analgesics
Propoxyphene or dextropropoxyphene	159 (7.9)	3 (0.8)	2 (0.9)
Pentazocine	0 (0.0)	–	–
Sedative or hypnotic drugs
Long-acting benzodiazepines (half-life ≥ 20 h)†	468 (23.2)	23 (5.9)	18 (8.2)
Chlordiazepoxide or diazepam	24 (1.2)	3 (0.8)	1 (0.5)
Meprobamate	73 (3.6)	2 (0.5)	2 (0.9)
Barbiturates	43 (2.1)	2 (0.5)	2 (0.9)
Drugs with anticholinergic properties
Anticholinergic antidepressants	150 (7.4)	26 (6.7)	16 (7.3)
Anticholinergic muscle relaxants and antispasmodic drugs	31 (1.5)	0 (0.0)	0 (0.0)
Anticholinergic H1 antihistamines	70 (3.5)	2 (0.5)	0 (0.0)
Diphenhydramine	7 (0.4)	0 (0.0)	0 (0.0)
Gastrointestinal antispasmodic drugs	6 (0.3)	1 (0.2)	0 (0.0)
Disopyramide	16 (0.8)	0 (0.0)	0 (0.0)
Nonsteroidal anti-inflammatory drugs
Indomethacin	2 (0.1)	0 (0.0)	0 (0.0)
Phenylbutazone	0 (0.0)	–	–
Antihypertensive
Methyldopa	15 (0.7)	5 (1.3)	3 (1.4)
Reserpine	1 (0.05)	0 (0.0)	0 (0.0)
Antiplatelet drugs
Dipyridamole	81 (4.0)	0 (0.0)	0 (0.0)
Ticlopidine	25 (1.2)	2 (0.5)	1 (0.5)
Hypoglycaemic
Chlorpropamide	7 (0.4)	0 (0.0)	0 (0.0)
Added criteria adapted to French practice
Concomitant use of two or more psychotropic drugs from the same therapeutic class	133 (6.6)	9 (2.3)	7 (3.2)
Concomitant use of two or more nonsteroidal anti-inflammatory drugs	56 (2.8)	0 (0.0)	0 (0.0)
Other anticholinergic drugs not mentioned by Beers	91 (4.5)	5 (1.3)	5 (2.3)

^*Pentoxifylline, nicergoline, dihydroergotamine, Ginkgo biloba, piracetam, …

^†Bromazepam, prazepam, clorazepate, nordazepam, …