Table 1.

Single increasing dose study design

Dose step	Week	Dose (mg)	Panel 1 n = 6 active n = 3 placebo	Panel 2 n = 6 active n = 3 placebo	Panel 3 n = 6 active n = 3 placebo
1	1	10	X
2	2	20		X
3	3	40			X
4	5	80	X
5	6	150		X
6	7	300			X
7	9	600	X
8	10	1000		X
9	11	1400			X