Table 2.

Important interactions of amiodarone with other drugs, classified by the degree of harm (see Table 1) and the quality of the evidence (see text)

Interacting drug	Category of harm	Evidence
Anaesthetics		R
Astemizole		D
Beta-adrenoceptor antagonists		D
Calcium channel blockers		R
Ciclosporin		A
Cimetidine		A
Colestyramine		R
Dextromethorphan		R
Digoxin		R
Disopyramide		R
Drugs that prolong the QT interval		A
Erythromycin i.v.		R
Fentanyl		R
Flecainide		R
Fluoroquinolones		R
Grapefruit juice		A
Ibutilide		R
Lidocaine		A
Lithium		A
Macrolide antibiotics		A
Oxygen, high dose		A
Phenytoin		A
Procainamide		R
Protease inhibitors		D
Quinidine		D
Rifampicin		R
Simvastatin		A
Sparfloxacin		R
Thioridazine		R
Warfarin		R