Table 2.

Summary of comparisons (continued)

Comparison or outcome	Studies	Participants	Statistical method used (fixed model)	Effect size, 95% CI	Statistically nonsignificant trend favouring
Midazolam i.m. vs. diazepam i.v. [7]
01 Risk of seizure continuation	1	24	RR	0.85 (0.06, 12.01)
02 Requirement for ventilatory support	1	24	RR	0.85 (0.06, 12.01)
03 Adverse effects	1	24	RR	0.85 (0.06, 12.01)
04 Continuation of status requiring a different drug or general anaesthesia	1	24	RR	0.85 (0.06, 12.01)
Diazepam i.v. vs. placebo i.v. [5]
01 Risk of seizure continuation	1	139	RR	0.73 (0.57, 0.92)
02 Requirement for ventilatory support	1	139	RR	0.39 (0.16, 0.94)
03 Adverse effects	1	139	RR	0.46 (0.20, 1.04)	Diazepam
04 Continuation of status requiring a different drug or general anaesthesia	1	139	RR	0.73 (0.57, 0.92)
05 Death	1	139	RR	0.28 (0.08, 0.98)
Diazepam gel vs. placebo gel (rectal) [6, 8]
01 Risk of seizure continuation	2	165	RR	0.43 (0.30, 0.62)
02 Adverse effects	2	165	RR	1.50 (0.94, 2.37)	Placebo gel
Diazepam 30 mg rectal vs. diazepam 20 mg rectal [13]
01 Risk of seizure continuation	1	39	RR	0.39 (0.18, 0.86)
02 Sedation	1	39	RR	0.90 (0.53, 1.53)
Diazepam plus phenytoin i.v. vs. phenobarbital i.v. [9, 10]
01 Risk of seizure continuation	1	36	RR	4.00 (0.98, 16.30)	Phenobarbital
02 Requirement for ventilatory support	1	36	RR	1.00 (0.40, 2.52)
03 Adverse effects	2	222	RR	1.00 (0.77, 1.30)
04 Death	1	36	RD	0.00 (−0.10, 0.10)
Diazepam plus phenytoin i.v. vs. phenobarbital i.v. (premonitory status) [9]
01 Risk of seizure continuation	1	186	RR	1.06 (0.76, 1.47)
Diazepam plus phenytoin i.v. vs. phenytoin i.v. (9)
01 Risk of seizure continuation	1	196	RR	0.78 (0.59, 1.04)	Diazepam plus phenytoin
02 Adverse effects	1	196	RR	1.16 (0.86, 1.56)
Phenobarbital i.v. vs. phenytoin i.v. [9]
01 Risk of seizure continuation	1	186	RR	0.78 (0.57, 1.06)	Phenobarbital
02 Adverse effects	1	186	RR	1.09 (0.81, 1.47)