Table 5.
Dose given and pharmacokinetic parameters for intravenously administered 99mTc-DTPA
| Meana | Range | |
|---|---|---|
| Dosei.v. (MBq) | 5.2 | (4.9–5.6) |
| AUC (kBq l−1 h) | 762 | (561–902) |
| AUCextrapolated (%) | 8.1 | (3.0–16.4) |
| t1/2 (h) | 2.1 | (1.5–3.3) |
| CL (l h−1) | 6.8 | (5.6–9.0) |
| Vss (l) | 17 | (14–20) |
| MRT (h) | 2.5 | (1.7–3.6) |
| Ae (MBq) | 5.3 | (4.9–5.8) |
| fe (%) | 101.6 | (96.7–109.3) |
a
geometric mean except for AUCextrapolated and MRT (arithmetic means).
Vss volume of distribution under steady-state conditions, calculated as CL × MRTi.v.
MRT mean residence time, calculated as AUMC/AUC where AUMC is the area under the curve of first moment of the plasma concentration vs. time.