Figure 7.
Dynamics of the hypothalamic–pituitary–gonadal axis compartments. Population-predicted drug, feedback, luteinizing hormone (LH) pool, LH and testosterone profiles after single subcutaneous administration of 3.75 mg of the gonadotropin-releasing hormone (GnRH) agonist triptorelin (dashed line) and 200 mg of the GnRH receptor blocker degarelix (solid line). The dotted line represents the castration concentration of 0.5 ng ml−1