Table 2.
Blood glucose variable | Placebo (control) phase | Clarithromycin phase | Grapefruit juice phase |
---|---|---|---|
Decremental AUC(0,3 h) (mmol l−1 h) | 3.11 ± 1.57 | 2.41 ± 1.47 | 2.08 ± 1.57 |
Mean difference from control phase (95% CI) | −0.70 (−2.31, 0.92) | −1.03 (−2.78, 0.73) | |
Decremental AUC(0,7 h) (mmol l−1 h) | 5.28 ± 3.25 | 3.79 ± 2.32 | 3.38 ± 4.07 |
Mean difference from control phase (95% CI) | −1.48 (−4.72, 1.76) | −1.89 (−6.33, 2.54) | |
Maximum increase (mmol l−1) | 0.80 ± 0.70 | 1.29 ± 0.89 | 1.07 ± 0.75 |
Mean difference from control phase (95% CI) | 0.49 (−0.41, 1.39) | 0.27 (−0.47, 1.00) | |
Maximum decrease (mmol l−1) | 2.47 ± 0.70 | 2.49 ± 0.47 | 2.18 ± 0.71 |
Mean difference from control phase (95% CI) | 0.03 (−0.76, 0.81) | −0.28 (−1.18, 0.61) |
Data are mean values ± SD unless otherwise shown. AUC(0,3 h), area under curve from time zero to 3 h; AUC(0,7 h), area under curve from time zero to 7 h.