Table 3.
Mean pharmacokinetic parameters calculated from creatinine clearance data in ventilated and nonventilated patients
| Without mechanical ventilation | With mechanical ventilation | |||
|---|---|---|---|---|
| Parameters | Males | Females | Males | Females |
| n | 27 | 7 | 11 | 5 |
| Creatinine clearance (ml min−1) | 114 | 103 | 93 | 87 |
| Clearance (l h−1) | 7.2 | 6.6 | 6.1 | 5.7 |
| Distribution volume of the central compartment (l) | 18.8 | 18.8 | 18.8 | 18.8 |
| Inter-compartmental clearance (l h−1) | 6.9 | 6.9 | 6.9 | 6.9 |
| Distribution volume of the peripheral compartment (l) | 4.0 | 9.3 | 12.8 | 30.6 |
| Volume of distribution (l) | 22.8 | 28.1 | 31.6 | 49.4 |
| Elimination rate (h−1) | 0.384 | 0.350 | 0.323 | 0.305 |
| Half-life (h) | 1.81 | 1.98 | 2.15 | 2.27 |