Table 1.
Comparison of the temperament and character inventory (TCI) subitem scores among phenotypes assumed by CYP2D6 genotypes
| UM (n = 4) | EM (n = 262) | IM (n = 75) | PM (n = 1) | Significance | |
|---|---|---|---|---|---|
| Novelty seeking | 18.3 (16.7, 19.8) | 21.4 (20.9, 22.0) | 21.5 (20.4, 22.5) | 27 | NS |
| Harm avoidance | 19.3 (13.2, 25.3) | 19.8 (19.0, 20.6) | 20.0 (18.6, 21.2) | 17 | NS |
| Reward dependence | 17.5 (15.9, 19.1) | 14.7 (14.3, 15.1) | 15.5 (14.7, 16.2) | 15 | NS |
| Persistence | 4.8 (1.2, 8.3) | 4.4 (4.1, 4.6) | 4.2 (3.8, 4.6) | 7 | NS |
| Self-directedness | 32.0 (24.1, 40.0) | 26.1 (25.3, 26.9) | 26.8 (25.2, 28.4) | 27 | NS |
| Co-operativeness | 31.5 (27.3, 35.7) | 28.0 (27.4, 28.6) | 28.4 (27.2, 29.6) | 32 | NS |
| Self-transcendence | 7.8 (4.5, 11.0) | 10.7 (10.1, 11.3) | 9.6 (8.4, 10.7) | 13 | NS |
Data are mean (95% confidence interval); UM; ultra rapid metabolizer, EM, extensive metabolizer, IM; intermediate metabolizer, PM; poor metabolizer.