Table 3.
Development of reflux symptoms in association with calcium antagonist therapy
| Nifedipine | Amlodipine | Felodipine | Verapamil | Diltiazem | Total | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gastrointestinal symptom | n | % | n | % | n | % | n | % | n | % | n | % |
| Heartburn | 13 | 15.3 | 12 | 14.1 | 12 | 14.1 | 14 | 16.5 | 6 | 7.1 | 57 | 67.1 |
| Indigestion | 9 | 10.6 | 2 | 2.4 | 4 | 4.7 | 11 | 12.9 | 1 | 1.2 | 27 | 31.8 |
| Acid reflux | 21 | 24.7 | 13 | 15.3 | 20 | 23.5 | 14 | 16.5 | 7 | 8.2 | 75 | 88.2 |
| Chest pain | 9 | 10.6 | 7 | 8.2 | 10 | 11.8 | 4 | 4.7 | 3 | 3.5 | 33 | 38.8 |
| Acid stomach | 7 | 8.2 | 4 | 4.7 | 2 | 2.4 | 6 | 7.1 | 2 | 2.4 | 21 | 24.7 |
| Bloating | 4 | 4.7 | 5 | 5.9 | 2 | 2.4 | 3 | 3.5 | 0 | 0.0 | 14 | 16.5 |
| Burning throat | 7 | 8.2 | 2 | 2.4 | 4 | 4.7 | 8 | 9.4 | 4 | 4.7 | 25 | 29.4 |
| Bitter taste | 3 | 3.5 | 1 | 1.2 | 3 | 3.5 | 0 | 0.0 | 2 | 2.4 | 9 | 10.6 |
| Other | 2 | 2.4 | 1 | 1.2 | 1 | 1.2 | 0 | 0.0 | 0 | 0.0 | 4 | 4.7 |
n, No. of patients; %, (n÷ 85) × 100 nTotal = Σn; nTotal% = (nTotal÷ 85) × 100.