Table 4.

Exacerbation of reflux-related symptoms after calcium antagonist (CA) exposure

	Patients with pre-existing symptoms prior to CA therapy		Patients with symptom exacerbation after CA therapy
CA	n	%	n	%	P-value, McNemar's test for paired proportions
Nifedipine	28	21.5	15	53.6	<0.0001
Amlodipine	31	23.8	19	61.3	<0.0001
Felodipine	28	21.5	15	53.6	<0.0001
Verapamil	27	20.8	8	29.6	<0.0160
Diltiazem	16	12.4	2	12.5	<0.5000
Total	130	100.0	59	45.4