Table 1.

Population pharmacokinetic parameters for stavudine in 272 children and the results of the boostrap validation

	Final model
	Original data set		Boostrap*
Parameter	Mean	SE	Median	CI
TV (CL/F) (l h−1)	16.5	0.74	16.1	12.8–17.9
CL/F, θage	0.40	0.023	0.40	0.34–0.45
TV (V/F) (l)	40.9	2.9	39.9	33.7–46.7
V/F, θage	0.40	0.034	0.39	0.29–0.46
D (h)	1.72	0.13	1.65	0.50–2.00
ω2CL/F	0.143	0.024	0.137	0.09–0.18
ω2V/F	0.102	0.043	0.087	0.01–0.19
COVCL,V	0.090	0.030	0.081	0.02–0.14
Proportional residual variability, σ12	0.23	0.022	0.23	0.19–0.27
Additive residual variability, σ22	0.00041	0.00022	0.00037	3.7 × 10–11–0.0012

^*Results of 1000 boostrap analyses; SE standard error of the estimate; TV typical value of the corresponding PK parameter;

θ _covariateinfluential factor for covariate; D the duration of the absorption phase; ω²interindividual variability; COV_CL,Vcovariance between ηs of CL/F and V/F; CI nonparametric 95% confidence interval.