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Pharmcokinetic data of CNS 5161 (mean ± SD) in the different dosage cohorts
| Cohort 1 125 µg 12 | Cohort 2 250 µg 12 | Cohort 3 500 µg 12 | |
|---|---|---|---|
| t1/2 (h) | 8.2 ± 3.4 | 8.7 ± 3.7 | 8.3 ± 1.6 |
| Cmax (pg ml−1) | 331.6 ± 204.9 | 876.0 ± 582.0 | 1056.7 ± 484.0 |
| AUC0−24 h (h pg−1 ml−1 µg−1) | 1772.3 ± 565.6 | 4348.2 ± 915.9 | 7017.3 ± 2093.3 |
