Table 1.
Steady-state concentrations of clozapine at 400 mg day−1 (n = 18)*
Item | Range | Mean | SD |
---|---|---|---|
CLZ (ng ml−1) | 202.2–1770.6 | 544.3 | 389.0 |
Normalized CLZ concentration† | 7.22–57.86 | 19.74 | 12.82 |
Normalized NCLZ concentration† | 3.48–23.63 | 9.18 | 5.65 |
Normalized sum concentration† | 12.07–79.94 | 29.27 | 18.34 |
NCLZ/CLZ ratio | 0.26–0.76 | 0.487 | 0.133 |
400 mg day−1for at least 7 days.
ng ml−1 mg−1 day−1 kg−1body weight. CLZ, Clozapine; NCLZ, norclozapine.