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Plasma concentration–time curves of gliclazide at steady state in CYP2C19*1 homozygotes (n = 5) (□), CYP2C19* heterozygotes (n = 9) (▵) and CYP2C19 poor metabolizers (n = 3) () after multiple oral doses of 30 mg of gliclazide MR. All data indicate mean ± SE