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Schematic illustration of the interaction between budesonide, endogenous ACTH and endogenous cortisol in the surge-based model. The concentration of budesonide (Cbud) suppressed the production of endogenous ACTH thereby decreasing the concentration of ACTH and lowering the peak concentrations (Surge Amplitude). The broken line shows the baseline values for ACTH and the continuous line the values after treatment with budesonide. ACTH governs the production of cortisol
