Table 1.
Population pharmacokinetic parameters for budesonide after a single dose of 1600μg in healthy volunteers using a mixed effects model
| Parameters | Estimate | Relative SE | Brief definition of symbols |
|---|---|---|---|
| CL (l h−1) | 81.5 | Clearance for budesonide | |
| V (l) | 219 | Volume of distribution of budesonide | |
| ka (h−1) | 3.72 | First order absorption rate constant for budesonide | |
| ω CL | 38% | 14% | Interindividual variability for CL (%CV) |
| ωV | 39% | 15% | Interindividual variability for V (%CV) |
| ωka | 25% | 41% | Interindividual variability for ka(%CV) |
| σ | 14% | 2% | Proportional error (%CV) |
| OFV | −216 | Objective function value |