Table 4.
Estimated odds ratio (95% confidence interval) from the multivariate analysis of baseline, age, tipifarnib AUC and treatment duration as predictors of haematological toxicity
| Haematological toxicity | Solid tumour | AML |
|---|---|---|
| Neutropenia | ||
| Baseline PC (Grade ≥1 vs. Grade 0) | – | 4.03 (2.65, 6.96)* |
| Age (≥65 years vs <65 years) | 1.66 (0.91, 3.00) | 1.01 (0.41, 2.51) |
| Exposure (AUC, mg l−1 h) | 1.69 (1.47, 1.95)* | 1.03 (0.90, 1.18) |
| Duration (week) | 1.13 (1.05, 1.21)* | 2.22 (1.29, 3.83)* |
| Thrombocytopenia | ||
| Baseline PC (Grade ≥1 vs. Grade 0) | 2.63 (1.55, 4.48)* | 3.84 (1.85, 7.98)* |
| Age (≥65 years vs <65 years) | 1.35 (0.67, 2.72) | 1.91 (0.48, 7.68) |
| Exposure (AUC, mg l−1 h) | 1.41 (1.21, 1.63)* | 1.16 (0.91, 1.49) |
| Duration (week) | 1.16 (1.06, 1.26)* | 1.21 (0.88, 1.67) |
*
P < 0.05.