Table 1.

DPD activity and 5FU toxicity in this case series of 131 patients

		DPD activity (pmol min−1 g−1)			Statistics
		n	median	Q1–Q3*	Mann–Whitney test
Lethal toxicity	No	122	193	134–271	P = 0.002
	Yes	9	61	22–169
Central neurotoxicity	Grade 0–1	112	207	146–273	P< 0.001
	Grade 2	19	66	44–130
Mucositis	Grade 0-1-2-3	82	214	155–274	P< 0.001
	Grade 4	49	135	64–251
Diarrhoea	Grade 0-1-2-3	109	209	143–273	P< 0.001
	Grade 4	22	120	68–176
Neutropenia	Grade 0-1-2-3	94	210	152–272	P< 0.001
	Grade 4	37	122	72–235
Thrombopenia	Grade 0-1-2-3	98	207	144–274	P = 0.005
	Grade 4	33	131	85–239

^*Q1 and Q3 represent the first and third quartile.