Table 2.
Population mean (% coefficient of variation) of desloratadine pharmacokinetic parameter estimates and predicted dose by age group
Age group | V/F (l) | ka (h−1) | CL/F (l h−1) | Predicted dose (mg) (range)a |
---|---|---|---|---|
≥6 months−<1 year | 470 (15) | 27.8 (35) | 1.01 (0.66–1.37) | |
0.922 (12) | ||||
≥1 year−≤2 years | 499 (13) | 35.5 (51) | 1.29 (0.63–1.96) | |
Adult | 2249 (23) | 137 (58) | – |
Range based on ± 1 SEM.