Table 4.
Mean (% coefficient of variation, estimated using standard deviation) and median predicted desloratadine parameters by age
| Mean (% coefficient of variation) | Median | |||||
|---|---|---|---|---|---|---|
| Parameter | ≥6 months–<1 yeara | ≥1 year–≤2 yearsa | Adultsb | ≥6 months–<1 yeara | ≥1 year–≤2 yearsa | Adultsb |
| Cmax (ng ml−1) | 1.69 (49) | 1.56 (46) | 1.94 (42) | 1.49 | 1.41 | 1.69c |
| tmax (h) | 3.16 (22) | 3.10 (28) | 3.22 (23) | 3.12 | 2.94 | 3.11c |
| AUC(0,∞) (ng ml−1 h) | 38.7 (65) | 34.4 (101) | 43.2 (81) | 29.3 | 19.0 | 34.4c |
| ka (h−1) | 0.959 (18) | 0.929 (17) | 0.956 (29) | 0.950 | 0.944 | 0.912 |
| CL/F (l h−1) | 34.7 (66) | 43.0 (55) | 155 (47) | 30.1 | 40.3 | 146 |
| t1/2 (h) | 14.6 (77) | 12.4 (88) | 12.2 (44) | 10.5 | 8.40 | 10.9 |
| V/F (l) | 494 (32) | 518 (29) | 2373 (33) | 473 | 479 | 2314 |
a
Parameter from combined dose (0.625 mg and 1.25 mg)
b
Parameter associated with 5 mg dose
c
Median values of estimated noncompartmental parameters: AUC(0, ∞) = 39.6 ng ml −1 h, C max = 1.84 ng ml −1, tmax = 4.5 h.