Table 2.

Clinical and electrocardiographic abnormalities after venlafaxine overdose, within the whole group (n = 235) and subset that ingested only venlafaxine (n = 81)

		Whole group	Venlafaxine alone
Mydriasis (>6 mm)	Women	65 (38.2%)**	29 (48.3%)**
	Men	21 (32.3%)**	11 (52.4%)**
	Both	86 (36.6%)**	40 (49.4%)**
Heart rate >100 min−1	Women	71 (43.6%)**	41 (70.7%)**†
	Men	23 (36.5%)**	7 (35.0%)**
	Both	94 (40.0%)**	38 (48.7%)**
Systolic BP >140 mmHg	Women	37 (22.7%)**††	15 (12.9%)**††
	Men	27 (43.5%)**	12 (60.0%)**
	Both	64 (28.4%)**	27 (34.6%)**
Diastolic BP >85 mmHg	Women	40 (24.5%)**	20 (34.5%)**
	Men	20 (32.3%)**	8 (40.0%)**
	Both	60 (26.7%)**	28 (35.9%)**
PR >200 ms	Women	0 (–)	0 (–)
	Men	0 (–)	0 (–)
	Both	0 (–)	0 (–)
QRSd >120 ms	Women	7 (5.3%)	1 (2.7%)
	Men	2 (3.6%)	1 (5.0%)
	Both	9 (4.8%)	2 (2.9%)
QT >450 ms	Women	0 (–)	0 (–)
	Men	0 (–)	0 (–)
	Both	0 (–)	0 (–)
QTc >450 ms	Women	17 (10.5%)**	4 (7.0%)*
	Men	7 (11.1%)**	4 (19.0%)**
	Both	24 (10.7%)**	8 (10.3%)**

Data presented as the absolute number and percentage of evaluable data in parentheses.

^*P < 0.05

^**P < 0.005 by binomial testing, assuming 0.025% population chance.

^†P < 0.01

^††P < 0.005 between men and women by two-tailed proportional χ² test with Yates' correction.