Table 2.
Basic population pharmacokinetic model for melphalan
| Pharmacokinetic parameter | Population estimate (θ) (%RSE) | Interindividual variability* (%RSE) | 95% CI |
|---|---|---|---|
| CL (l h−1) | 10.1 (10%) | 60 (20%) | 9.39, 10.81 |
| V (l) | 4.81 (14%) | 58 (38%) | 4.14, 5.48 |
| k12 (h−1) | 1.81 (18%) | 61 (18%) | 1.08, 2.54 |
| k21 (h−1) | 1.86 (12%) | 64 (39%) | 1.05, 2.67 |
| Residual variability† | |||
| Proportional (%) | 0.092 (19%) | ||
| Additive (mg l−1) | 0.007 (69%) | ||
| Objective function | −80.429 | ||
*
Interindividual variability was expressed as percentage coefficient of variation and was calculated by taking the square root of ETA (the variance associated with the parameter values) and multiplying by 100.
†
Proportional component of residual variability was expressed as %CV, while the additive component was expressed as standard deviation. RSE, Relative standard error, calculated as standard error (SE)/population estimate and expressed as a percentage; 95% CI, lower and upper limits of the 95% confidence interval, calculated as θ ± 2 SE.