Table 3.

Backwards elimination: effect on objective function value of deletion of statistically significant covariates in the covariate population pharmacokinetic model for melphalan

Model	OFV	Δ OFV	Significance	Interpretation
CL = f(WT, CPT, GFR)	−177.345			Full Model
V = f(WT)
CL = f(WT, CPT)	−164.55	+12.795	P< 0.01	GFR affects CL
V = f(WT)
CL = f(WT, GFR)	−162.328	+15.017	P< 0.01	CPT affects CL
V = f(WT)
CL = f(WT, CPT, GFR)	193.879	+371.224	P< 0.01	WT affects V
CL = f(CPT, GFR)	−132.238	+45.107	P< 0.01	WT affects CL
V = f(WT)