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. 2007 Feb 23;64(2):151–164. doi: 10.1111/j.1365-2125.2007.02862.x

Table 7.

Melphalan dose (mg)* required to achieve a target AUC of 9 µg ml−1 h−1 (the median value obtained by children in the 140 mg m−2 dose group, no carboplatin), in children with various weights and renal function, with and without prior carboplatin therapy

No carboplatin Carboplatin
GFR (ml min–1 1.73 m–2)
Weight (kg) 50 70 90 110 130 150 170 190 210 230 250 50 70 90 110 130 150 170 190 210 230 250
10 48 54 61 68 75 81 88 95 102 109 115 19 26 33 39 46 53 60 67 73 80 87
15 63 70 76 83 90 97 104 110 117 124 131 34 41 48 55 61 68 75 82 89 95 102
20 78 85 92 99 105 112 119 126 132 139 146 50 56 63 70 77 84 90 97 104 111 117
25 93 100 107 114 121 127 134 141 148 155 161 65 72 79 85 92 99 106 112 119 126 133
30 109 116 122 129 136 143 149 156 163 170 177 80 87 94 101 107 114 121 128 135 141 148
35 124 131 138 144 151 158 165 172 178 185 192 96 102 109 116 123 129 136 143 150 157 163
40 139 146 153 160 167 173 180 187 194 200 207 111 118 124 131 138 145 152 158 165 172 179
45 155 161 168 175 182 189 195 202 209 216 223 126 133 140 146 153 160 167 174 180 187 194
50 170 177 184 190 197 204 211 217 224 231 238 141 148 155 162 169 175 182 189 196 203 209
55 185 192 199 206 212 219 226 233 240 246 253 157 164 170 177 184 191 197 204 211 218 225
60 201 207 214 221 228 234 241 248 255 262 268 172 179 186 192 199 206 213 220 226 233 240
65 216 223 229 236 243 250 257 263 270 277 284 187 194 201 208 214 221 228 235 242 248 255
70 231 238 245 252 258 265 272 279 285 292 299 203 209 216 223 230 237 243 250 257 264 270
75 246 253 260 267 274 280 287 294 301 308 314 218 225 232 238 245 252 259 265 272 279 286
80 262 269 275 282 289 296 302 309 316 323 330 233 240 247 254 260 267 274 281 288 294 301
*

Dose was obtained from population mean values.

As there is variability around the mean, dose would need to be individualized, by first administering a 10-fold lower test dose, measuring the AUC and using this information to determine the full dose required to target the desired AUC.