Table 7.
Melphalan dose (mg)* required to achieve a target AUC of 9 µg ml−1 h−1 (the median value obtained by children in the 140 mg m−2 dose group, no carboplatin), in children with various weights and renal function, with and without prior carboplatin therapy
No carboplatin | Carboplatin | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GFR (ml min–1 1.73 m–2) | ||||||||||||||||||||||
Weight (kg) | 50 | 70 | 90 | 110 | 130 | 150 | 170 | 190 | 210 | 230 | 250 | 50 | 70 | 90 | 110 | 130 | 150 | 170 | 190 | 210 | 230 | 250 |
10 | 48 | 54 | 61 | 68 | 75 | 81 | 88 | 95 | 102 | 109 | 115 | 19 | 26 | 33 | 39 | 46 | 53 | 60 | 67 | 73 | 80 | 87 |
15 | 63 | 70 | 76 | 83 | 90 | 97 | 104 | 110 | 117 | 124 | 131 | 34 | 41 | 48 | 55 | 61 | 68 | 75 | 82 | 89 | 95 | 102 |
20 | 78 | 85 | 92 | 99 | 105 | 112 | 119 | 126 | 132 | 139 | 146 | 50 | 56 | 63 | 70 | 77 | 84 | 90 | 97 | 104 | 111 | 117 |
25 | 93 | 100 | 107 | 114 | 121 | 127 | 134 | 141 | 148 | 155 | 161 | 65 | 72 | 79 | 85 | 92 | 99 | 106 | 112 | 119 | 126 | 133 |
30 | 109 | 116 | 122 | 129 | 136 | 143 | 149 | 156 | 163 | 170 | 177 | 80 | 87 | 94 | 101 | 107 | 114 | 121 | 128 | 135 | 141 | 148 |
35 | 124 | 131 | 138 | 144 | 151 | 158 | 165 | 172 | 178 | 185 | 192 | 96 | 102 | 109 | 116 | 123 | 129 | 136 | 143 | 150 | 157 | 163 |
40 | 139 | 146 | 153 | 160 | 167 | 173 | 180 | 187 | 194 | 200 | 207 | 111 | 118 | 124 | 131 | 138 | 145 | 152 | 158 | 165 | 172 | 179 |
45 | 155 | 161 | 168 | 175 | 182 | 189 | 195 | 202 | 209 | 216 | 223 | 126 | 133 | 140 | 146 | 153 | 160 | 167 | 174 | 180 | 187 | 194 |
50 | 170 | 177 | 184 | 190 | 197 | 204 | 211 | 217 | 224 | 231 | 238 | 141 | 148 | 155 | 162 | 169 | 175 | 182 | 189 | 196 | 203 | 209 |
55 | 185 | 192 | 199 | 206 | 212 | 219 | 226 | 233 | 240 | 246 | 253 | 157 | 164 | 170 | 177 | 184 | 191 | 197 | 204 | 211 | 218 | 225 |
60 | 201 | 207 | 214 | 221 | 228 | 234 | 241 | 248 | 255 | 262 | 268 | 172 | 179 | 186 | 192 | 199 | 206 | 213 | 220 | 226 | 233 | 240 |
65 | 216 | 223 | 229 | 236 | 243 | 250 | 257 | 263 | 270 | 277 | 284 | 187 | 194 | 201 | 208 | 214 | 221 | 228 | 235 | 242 | 248 | 255 |
70 | 231 | 238 | 245 | 252 | 258 | 265 | 272 | 279 | 285 | 292 | 299 | 203 | 209 | 216 | 223 | 230 | 237 | 243 | 250 | 257 | 264 | 270 |
75 | 246 | 253 | 260 | 267 | 274 | 280 | 287 | 294 | 301 | 308 | 314 | 218 | 225 | 232 | 238 | 245 | 252 | 259 | 265 | 272 | 279 | 286 |
80 | 262 | 269 | 275 | 282 | 289 | 296 | 302 | 309 | 316 | 323 | 330 | 233 | 240 | 247 | 254 | 260 | 267 | 274 | 281 | 288 | 294 | 301 |
Dose was obtained from population mean values.
As there is variability around the mean, dose would need to be individualized, by first administering a 10-fold lower test dose, measuring the AUC and using this information to determine the full dose required to target the desired AUC.