Table 1.
Numerical values used in the simulations
| Fixed effects parameters | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| θCL | θEC50 | θEmax | θTC50 | θα | θβ | ||||
| 10 | 25 | 0.8 | 1/2/3/4·θEC50 | −1.386 | 0.0224 | ||||
| Random effects parameters | |||||||||
| CV(CL) % | CV(EC50) % | CV(Emax) % | CV(TC50) % | CV(α) % | CV(β) % | ||||
| 0/20/30/50/100 | 40 | 0/30* | 0/30/50/75 | 0/25* | 0 | ||||
| Correlation levels | |||||||||
| ρ (CL < = > EC50) | ρ (CL < = > Emax) | ||||||||
| −0.8 | −0.2 | 0 | 0.2 | 0.8 | −0.8 | −0.2 | 0 | 0.2 | 0.8 |
The figures in bold indicate the values used in the default simulation setup.
*
The parameters are used within a logit transform and the numerical values for the standard deviation were ωEmax = 1.875 and ωα = 0.3465.