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. 2007 Apr 10;64(3):266–277. doi: 10.1111/j.1365-2125.2007.02887.x

Table 2.

Statistical power when introducing different magnitudes of correlation between CL and EC₅₀ or CL and E_max

	RDCT				RCCT				RBCT
	Model-based		Traditional		Model-based		Traditional		Model-based		Traditional
Magnitude of correlation	EC₅₀	E_max	EC₅₀	E_max	EC₅₀	E_max	EC₅₀	E_max	EC₅₀	E_max	EC₅₀	E_max
LOW dose range
−0.8	0.81	1	0.46	0.52	0.87	0.82	0.44	0.39	0.61	0.63	0.39	0.32
−0.2	0.81	0.86	0.46	0.47	0.82	0.79	0.47	0.44	0.61	0.60	0.39	0.39
0	0.85	0.85	0.50	0.50	0.80	0.80	0.46	0.46	0.61	0.61	0.39	0.39
0.2	0.86	0.83	0.51	0.45	0.81	0.78	0.46	0.44	0.61	0.60	0.39	0.40
0.8	0.94	0.80	0.46	0.22	0.86	0.81	0.46	0.38	0.61	0.61	0.39	0.33
WIDE dose range
−0.8	0.95	1	0.70	0.65	0.96	0.96	0.67	0.63	0.86	0.86	0.62	0.50
−0.2	0.95	0.96	0.70	0.71	0.95	0.95	0.71	0.71	0.86	0.85	0.62	0.62
0	0.96	0.96	0.72	0.72	0.95	0.95	0.70	0.70	0.86	0.86	0.62	0.62
0.2	0.96	0.95	0.73	0.69	0.95	0.95	0.71	0.69	0.86	0.87	0.62	0.62
0.8	0.99	0.93	0.63	0.34	0.96	0.96	0.68	0.63	0.86	0.86	0.62	0.52

The default parameter variability levels are used and the independent variable is biomarker.