Table 2.
Final covariate pharmacokinetic model parameter estimates
| Parameter (units) | Population mean (SE*) | %CV intersubject variance (SE*) | Bootstrap summary statistics Lower 95% CI | Median | Upper 95% CI |
|---|---|---|---|---|---|
| TVVmax (µg h−1) | 1020 (9.5) | 32 (31.8) | 651 | 979.5 | 1840 |
| WBC factor | 0.194 (8.5) | – | 0.081 | 0.192 | 0.382 |
| Km (µg l−1) | 338 (27.5) | 145 (37.2) | 226 | 420.5 | 849 |
| V1 (l) | 11.3 (15.0) | 84 (21.2) | 8.92 | 12.4 | 16.4 |
| Q (l h−1) | 1.05 (2.0) | Not estimated | 0.443 | 1.17 | 2.13 |
| V2 (l) | 41.5 (32.8) | 179 (27.9) | 21.3 | 35.4 | 73.2 |
| CCV residual error | 37.2 (2.0) | 31.0 | 37.0 | 40.0 | |
| Additive residual error (µg l−1) | 64.73 (19.3) | 37.2 | 61.5 | 113.6 |
*
As percentage coefficient of variation. WBC, White blood cell; CCV, constant coefficient of variation.