Table 3.
Final covariate model pharmacodynamic parameter estimates for WBC counts
| Parameter (units) | Population mean (SE*) | %CV interindividual variance (SE*) | Bootstrap summary statistics Lower 95% CI | Median | Upper 95% CI |
|---|---|---|---|---|---|
| Emax | 18.2 (39.1) | 244 (100) | 9.11 | 17.1 | 120 |
| EC50 (µg l−1) | 306 (39.9) | 775 (83.7) | 94.4 | 280 | 1800 |
| Kin (cells × 109 l−1 h−1) | 1.56 (35.4) | 172 (68.7) | 0.367 | 1.62 | 3.63 |
| Kout (h−1) | 0.029 (14.1) | Not estimated | 0.019 | 0.029 | 0.048 |
| Additive residual error (cells × 109 l−1) | 15.6 (38.1) | 6.83 | 15.0 | 20.2 |
*
As percentage coefficient of variation. WBC, White blood cell.