Table 2.

Fitted and derived parameters for the three-compartment model that was used to describe the pharmacokinetics of L-carnitine in end-stage renal disease patients undergoing haemodialysis

Patient	MSC	V1 (l)	k12 (h−1)	k21 (h−1)	k13 (h−1)	k31 (h−1)	V2app (l)	V3app (l)	T2 (h)	T3 (h)	Ac,base (µmol)
1	1.97	11.84	0.127	0.118	0.082	0.000056	12.74	17426	8.47	17949	196.1
2	1.76	11.29	0.166	0.07	0.056	0.000091	26.77	6940	14.29	10977	163.3
3	2.5	7.04	0.328	0.237	0.179	0.000205	9.74	6139	4.22	4871	96.8
4	3.13	11.8	0.083	0.196	0.138	0.000438	5.00	3718	5.10	2283	268.7
5	2.15	12.92	0.191	0.091	0.126	0.000393	27.12	4147	10.99	2547	305.4
6	2.22	11.88	0.142	0.105	0.084	0.000078	16.07	12741	9.52	12768	327.2
7	4.46	5.52	4.422	2.763	0.388	0.001685	8.83	1271	0.36	594	66.8
8	2.13	9.81	0.126	0.104	0.098	0.000083	11.89	11649	9.62	12117	141.8
9	2.33	7.93	0.249	0.059	0.039	0.000076	33.47	4073	16.95	13170	216.0
10	3.11	8.19	0.271	0.138	0.092	0.092243	16.08	8	7.25	11	205.6
11	1.52	7.66	0.178	0.058	0.061	0.000008	23.51	55261	17.24	118266	118.3
12	1.64	11.88	0.116	0.065	0.094	0.000128	21.20	8710	15.38	7800	243.5
Median	2.19	10.55	0.170	0.100	0.090	0.000110	16.07	6539	9.57	9388	200.8
Pooled data*	2.26	10.09	0.162	0.106	0.100	0.00014	15.42	7207	9.43	7143	214.7
Pooled SD		0.72	0.07	0.07	0.018	0.00016	12.22	5834	6.23	1286	15.3

The symbols used for the fitted and derived parameters are described in the text.

^*Values obtained by fitting model to pooled plasma concentration vs. time data.