Table 1.

Pharmacokinetic parameters of esomeprazole 40 mg once daily in fed and fasting healthy adult volunteers

	Day 1			Day 5
Parameter	Fed	Fasting	Ratio*	Fed	Fasting	Ratio*
AUC
n	35	43	35	43	44	43
µmol h−1 l−1	4.04 (3.2)	6.71 (4.3)	0.56 (0.50, 0.64)	9.47 (3.3)	12.31 (4.1)	0.78 (0.74, 0.82)
AUC0–t
n	44	44	NC	44	44	NC
µmol h−1 l−1	2.80 (3.2)	6.66 (4.1)		9.22 (3.3)	12.22 (4.1)
Cmax
n	44	44	35	44	44	43
µmol l−1	0.88 (1.1)	3.48 (1.5)	0.34 (0.28, 0.41)	2.45 (1.4)	5.37 (1.4)	0.47 (0.41, 0.52)
tmax, h†
n	44	44		44	44
Median	4.02	2.00	—	2.50	1.50	—
Range	0.77–9.00	1.00–4.02		0.77–8.00	0.77–4.50
t1/2, h†
n	37	44		43	44
Mean	1.53	1.07	—	1.47	1.28	—
Range	0.59–4.10	0.55–2.05		0.90–4.30	0.85–1.73

Values shown are geometric means (SD) unless otherwise indicated. AUC, Area under the plasma concentration–time curve; AUC_0–t, area under the plasma concentration–time curve from time 0 to the time of last quantifiable concentration; CI, confidence interval; C_max, maximum plasma esomeprazole concentration; t_max, time to peak esomeprazole concentration; t_1/2, elimination half-life.

^*Ratio (90% CI) of fed to fasting calculated for those subjects with profiles from both periods.

^†Arithmetic mean (range) or median (range).