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Metabolic bone marker (CTX-S and CTX-U) variations during 4 weeks of CHF 4227 administration, expressed as a % of baseline values (mean ± SEM). *Statistically significant difference between CHF 4227 and placebo after 28 days of treatment, P < 0.05, Dunnett's test. 5 mg (▪), 10 mg (□), 25 mg (▴), 50 mg (▵), 100 mg (•), Placebo (○)
