Figure 2. GABA_C receptors are not activated by spontaneous release at GABA_A synapses.

A, current traces from a terminal before and during application of TPMPA (50 μm), with the superimposed average mIPSCs in the two conditions (control, n = 100; TPMPA, n = 102). B, mean data from eight terminals showing that TPMPA reduced the tonic current but had no significant effect on mIPSC decay kinetics (τ₁, fast time constant; τ₂, slow time constant; τ₁%, percentage contribution of τ₁ to the decay). C, current traces from a terminal before and during application of the GAT-1 inhibitor NO-711 (3 μm), with the superimposed average mIPSCs in the two conditions (control, n = 74; NO-711, n = 43). D, mean data from eight terminals showing that NO-711 greatly potentiated the tonic current but had no effect on mIPSC decay kinetics. In B and D, error bars represent s.e.m., *P < 0.05.