Figure 2. The effect of kynurenate on mouse gastro-oesophageal vagal afferents.

Stimulus–response functions of mucosal (A, n = 5) and tension receptors (B, n = 6) to mucosal stroking and circumferential tension, respectively. The responses are before (•) and after exposure to kynurenate (0.1 μm (○), 0.3 μm (▪) and 1 μm (□)). Asterisks indicate significant difference from control using a two-way ANOVA (***P < 0.001). C, original recording of a mucosal receptor response to mucosal stroking with a 200 mg von Frey hair before (a) and after (b) exposure to kynurenate (1 μm). D, original recording of a tension receptor response to circumferential tension using a 4 g weight before (a) and after (b) exposure to kynurenate (1 μm).