Figure 8. Muscimol injection into commissural part of the solitary tract nucleus (commNTS) blocks peripheral chemoreflexes in vagotomized rats.
A, response of the splanchnic and phrenic nerves to peripheral chemoreceptor stimulation with i.v. cyanide (50 μg kg−1) in a urethane-anaesthetized rat before (left panel) and 5 min after a single midline injection of muscimol (1.75 mm, 30 nl: right panel) into commNTS. B, effect of muscimol on the cyanide-induced rise in MAP (*P < 0.05 when comparing effect of NaCN before and after muscimol; 7 rats). C, effect of muscimol on the cyanide-induced rise in sSND (*P < 0.05; 7 rats).