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. Author manuscript; available in PMC: 2008 Sep 7.
Published in final edited form as: Brain Res. 2007 Jul 27;1168:1–10. doi: 10.1016/j.brainres.2007.06.087

Figure 4. Adenosine A1 receptor inhibitor, xanthine amine congener (XAC), blocks AMP-induced stellation with no effect on AICAR-induced stellation in cultured rat cortical astrocytes.

Figure 4

Cells were infected with GFP adenovirus for 48 h. After 24 h, cell media was changed to SF DMEM overnight. Then cells were rinsed and maintained in either (A) HBSS or (B) SF DMEM containing vehicle (DMSO) or 10μM XAC for 5 min. Then either (A) 100μM AMP or (B) 4mM AICAR was added for 3 h. Percent stellation was calculated as number of stellate GFP-positive cells divided by total number of GFP-positive cells. Data are mean ± SEM (bars) of 4 independent experiments. * p = 0.005, ** p = 0.0044, *** p = 0.0014