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Evaluation of effect size of influential covariates. Darbepoetin alfa serum concentration profiles after a 100-µg fixed dose, simulated using the full covariate model fixed-effect parameters at the extremes of the ranges of the covariates body weight (solid line) and age (hashed line). 50 kg (
), 90 kg (
), 30 yr (
), 80 yr (
)
