Figure 2.

Tadalafil systemic exposures by subject group. Each box defines the 25th, 50th (median) and 75th percentiles of individual AUC values normalized to a 10-mg dose. Box width is proportional to the square root of sample size. The ‘whiskers’ extend from each box to the farthest value within an interquartile range (box height); symbols (○) indicate extreme values. H1, H2 and H3 denote the healthy subject control values for the renal impairment, end-stage renal failure (ESRF) and hepatic impairment studies, respectively. The reference line denotes the historical mean AUC of 4033 μg h⁻¹ ml⁻¹