Skip to main content
. 2006 Jul 21;63(1):24–35. doi: 10.1111/j.1365-2125.2006.02726.x

Table 2.

Geometric mean (CV%) pharmacokinetic parameters for tadalafil after administration of a single 10-mg dose

Parameter Male (N = 12)* Female (N = 12)* Elderly (N = 12) Young (N = 12) Healthy subjects (N = 12) Diabetic (N = 12) Healthy subjects (renal) (N = 8) Mild renal impair. (N = 5) Moderate renal impair. (N = 6) Healthy subjects (hepatic) (N = 8) Very mild hepatic impair. (N = 8) Mild hepatic impair. (N = 8) Moderate hepatic impair. (N = 8)
AUC (μg h l−1) 3565 (23) 4097 (28) 4881 (32) 3896 (43) 4249 (36) 3458 (38) 2868 (44) 6280 (46) 4911 (50) 5823 (74) 3961 (34) 5760 (52) 4049 (56)
Cmax (μg l−1) 142 (26) 140 (21) 196 (27) 183 (25) 193 (22) 184 (27) 183 (31) 217 (21) 220 (22) 180 (38) 133 (21) 146 (23) 101 (39)
tmax (h) 3.5 (1–8) 3.5 (2–8) 2.0 (1–4) 2.5 (1–6) 2.0 (1–8) 3.0 (1–4) 1.0 (0.5–3.0) 2.0 (2–4) 2.0 (0.5–3) 2.50 (0.5–4) 3.0 (0.5–4) 2.0 (0.5–6) 2.5 (0.5–4)
t1/2 (h) 16.6 (21) 19.8 (26) 21.6 (39) 16.9 (29) 17.1 (27) 13.8 (33) 14 (46) 26 (33) 22 (43) 24.2 (53) 24.7 (43) 34.9 (48) 37.8 (62)
CL/F (l h−1) 2.81 (23) 2.44 (28) 2.05 (32) 2.57 (43) 2.35 (36) 2.89 (38) 3.49 (44) 1.59 (46) 2.04 (50) 1.72 (74) 2.52 (34) 1.74 (52) 2.47 (55)
Vz/F (l) 67.2 (16) 69.8 (19) 63.9 (25) 62.5 (17) 58.2 (23) 57.4 (18) 71.8 (40) 59.2 (16) 65.9 (17) 59.9 (30) 90.1 (19) 87.5 (25) 135 (55)
*

Multiple-dose pharmacokinetics are discussed in text.

Median (min–max) data. CV%, Coefficient of variation.