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Mean ± SD lasofoxifene plasma concentration–time profiles following administration of a single 0.25-mg lasofoxifene dose alone and during daily dosing with 400 mg ketoconazole or with 400 mg fluconazole. Lasofoxifene (alone) (•), lasofoxifene + ketoconazole (○), lasofoxifene + fluconazole (▾)
