Table 2.

Summary of pharmacokinetic parameters (mean ± SD) for lasofoxifene alone or when coadministered with ketoconazole, fluconazole (Study 1) or alone or with paroxetine (Study 2)

	Study 1			Study 2
Parameter	Lasofoxifene alone	Lasofoxifene + ketoconazole	Lasofoxifene + fluconazole	Lasofoxifene alone	Lasofoxifene + paroxetine
N	15	15	15	10	10
Tmax, h	15.4 ± 7.4	9.6 ± 4.5	21.3 ± 12.4	13.0 ± 6.0	11.8 ± 6.6
Cmax, ng ml−1	0.218 ± 0.033	0.249 ± 0.074	0.200 ± 0.037	0.203 ± 0.050	0.243 ± 0.083
AUC0–∞, ng h ml−1	52.7 ± 9.5	63.6 ± 14.0	55.3 ± 12.7	41.4 ± 4.5	56.4 ± 10.2
t1/2, h	196 ± 45.3	190 ± 40.0	204 ± 30.6	168 ± 31.7	202 ± 37.2

C_max, Maximum plasma concentration; AUC_0–∞, area under plasma concentration–time profile from time zero extrapolated to infinite time; T_max, time to reach C_max; t_1/2, terminal half-life.