Table 3.

Least square mean ratio (90% confidence interval) C_max and AUC of lasofoxifene administered with ketoconazole, fluconazole or paroxetine using lasofoxifene alone as reference

Treatment	Parameter	Ratio (%)	90% CI
Ketoconazole	Cmax	111	98.4, 127
	AUC0–∞	120	105, 136
Fluconazole	Cmax	91.3	80.3, 104
	AUC0–∞	104	91.4, 118
Paroxetine	Cmax	118	95.6, 146
	AUC0–∞	135	120, 152

C_max, Maximum plasma concentration; AUC_0–∞, area under plasma concentration–time profile from time zero extrapolated to infinite time.