Table 1.

Pharmacokinetic parameters for zolpidem (10 mg administered orally) without (control) and following pretreatment with oral voriconazole (400 mg twice daily on the first day and 200 mg twice daily on the second day) to 10 healthy males

Parameter	Control phase	Voriconazole phase	95% CI on the difference between phases	Geometric mean ratio and 90% CI
Zolpidem
Cmax (ng ml−1)	112 ± 50	135 ± 47*	0.32, 45.3	1.23 (1.05, 1.45)
% of control (range)	100	120 (90–147)
tmax (h)	1 (0.5–4.0)	1.5 (0.5–3.0)
AUC0–∞ (ng ml−1 h)	528 ± 337	743 ± 412†	119, 310	1.48 (1.29, 1.74)
% of control (range)	100	141 (117–288)
t1/2 (h)	3.2 ± 1.8	4.1 ± 1.6‡	0.27, 1.45	1.35 (1.15, 1.62)
% of control (range)	100	128 (100–270)

Data are presented as mean±SD, except for t_max, presented as median and range. CI, Confidence interval; C_max, peak plasma concentration; t_max, time to peak plasma concentration; AUC_0–∞, area under the zolpidem plasma concentration–time curve; t_1/2, elimination half-life.

^*Significantly (P < 0.05) different from control.

^†Significantly (P < 0.001) different from control.

^‡Significantly (P < 0.01) different from control.